Pressure BioSciences, Inc. Reports Financial Results for the First Quarter of 2010 and Provides Business Update

SOUTH EASTON, Mass., May 17, 2010 (GLOBE NEWSWIRE) -- Pressure BioSciences, Inc. (Nasdaq:PBIO) ("PBI" or the "Company") today announced its financial results for the first quarter of 2010.

Total revenue for the first quarter of 2010 was $290,813 compared to $306,762 for the comparable period in 2009. Revenue from the sale of PCT products and services was $189,150 for the three months ended March 31, 2010 compared to $222,142 for the same period in 2009. During the first quarter of 2010, the Company completed the installation of ten Pressure Cycling Technology (PCT) Sample Preparation Systems (PCT SPS), equal to the number of PCT SPS installations for the same period in 2009. All ten installations in the 2010 first quarter were domestic placements, compared to seven domestic installations and three international sales for the same quarter in 2009.

Operating loss for the first quarter of 2010 was $911,431 compared to $849,911 for the same period in 2009. After the exclusion of non-cash charges, operating cash burn for the first quarter of 2010 was approximately $750,000, compared to approximately $655,000 for the first quarter of 2009.

Loss per common share -- basic and diluted -- was $.49 for the first quarter of 2010 compared to $.33 for 2009. The first quarter 2009 loss per common share included an income tax refund of $623,262.

Joseph L. Damasio, Jr., Corporate Controller, commented: "The Q1 2010 operating loss of $911,431 included non-cash charges of depreciation/amortization expenses of approximately $50,000, and stock-based compensation to employees and consultants of approximately $109,000. Excluding these non-cash charges, operating cash burn for Q1 2010 was approximately $750,000 compared to approximately $655,000 for the first quarter of 2009. This increase was primarily due to greater than usual patent related expenses incurred in the protection of our technology platform. We expect patent related expenses to return to previous, lower levels for the remainder of the fiscal year."

Mr. Damasio continued: "Our first quarter 2010 results were also adversely affected by the two historic mid-Atlantic snow storms of February 2010. We believe that the loss of two full weeks by one-half of our outside sales team was the major factor resulting in the first decline in year-over-year quarterly revenue since the second quarter of 2008. Because we believe this was an atypical occurrence, we remain optimistic that revenue and installations for 2010 will exceed those for 2009."

Richard T. Schumacher, President and CEO of Pressure BioSciences, Inc. said: "We reported on a number of significant achievements during the first quarter and April of 2010. To that end, we believe our reported funding successes have helped greatly to strengthen our financial position. We further believe that our reported operational and technical successes are a clear indication that market acceptance of PCT is close. Among these reported achievements were:

  --  Presentations by scientists from the FDA (improved quality control
      measures for swine and seasonal flu vaccine), Thermo Fisher
      Corporation/University of Montreal (enhanced biomarker discovery),
      Target Discovery (detection of an ovarian cancer marker), Harvard School
      of Public Health (improved detection of membrane proteins), the
      University of New Hampshire (improved detection of bacteria), The
      University of North Texas (improved forensics testing), the University
      of California -- Davis (improved digestion of proteins), and the Barnett
      Institute of Northeastern University (enhanced analysis of
      glycoprotein-based drugs and drug candidates).

  --  The announcement of a strategic product licensing, manufacturing,
      co-marketing, and collaborative research and development agreement with
      Target Discovery, Inc.

  --  The March close on the sale of approximately $500,000 of units in an
      "above-market" financing

  --  The award of five additional PCT patents

  --  A 100% exercise of February 2009 Series A warrants, netting over $1.2
      million to PBI in April

  --  The announcement of an all day Symposium on May 21st at the Harvard
      Medical School on the Applications of Ultra-high Pressure in
      Biotechnology. The Symposium is being co-hosted by the Laboratory for
      Innovative Translational Technologies (HC-LITT) and the Central
      Laboratory (HCCL) of Harvard Catalyst | The Harvard Clinical and
      Translational Science Center (Harvard CTSC), and the Proteomics Resource
      at Harvard School of Public Health (HPR)

Mr. Schumacher continued: "We have only a few spaces left before we reach the maximum of 100 attendees for this Friday's High Pressure Symposium at Harvard Medical School. At the present time, the majority of registrations have come from the scientific community, but media, investors, and potential strategic partners have also signed up for the Symposium. Together with our colleagues from HC-LITT, HCCL, and HPR, we believe that this Friday's Symposium offers a wonderful opportunity for key researchers from around the country to highlight the many exciting and important applications of cycled, ultra-high pressure in biotechnology."

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (PBI) is a publicly traded company focused on the development of a novel, enabling technology called Pressure Cycling Technology (PCT). PCT uses cycles of hydrostatic pressure between ambient and ultra-high levels (up to 35,000 psi and greater) to control bio-molecular interactions. PBI currently holds 14 US and 10 foreign patents covering multiple applications of PCT in the life sciences field, including genomic and proteomic sample preparation, pathogen inactivation, the control of chemical reactions, immunodiagnostics, and protein purification. PBI currently focuses its efforts on the development and sale of PCT-enhanced enzymatic digestion products designed specifically for the mass spectrometry marketplace, as well as sample preparation products for biomarker discovery, soil and plant biology, forensics, histology, and counter-bioterror applications.

Disclaimer

Harvard CTSC, HC-LITT, HCCL, and HPR do not endorse any company or product. The opinions expressed in the Symposium are those of the speakers, and don't represent the views of Harvard Catalyst, Harvard University and its affiliated academic health care centers, the National Center for Research Resources, or the National Institutes of Health.

Forward Looking Statements

Statements contained in this press release regarding the Company's intentions, hopes, beliefs, expectations, or predictions of the future are "forward-looking'' statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward looking statements include statements regarding the expectation that patent related expenses will return to previous levels for the remainder of the 2010 fiscal year; that our Q1 2010 financial results were primarily adversely affected by historic snow storms; that 2010 revenue and installations will exceed those reported in 2009; that our reported funding successes have greatly strengthened our financial position; that our operational and technical successes indicate that market acceptance of PCT is close; and the anticipated advantages and benefits of the Company's products and technology and that scientists and research laboratories will able to corroborate the benefits of pressure cycling technology that have been previously reported. These statements are based upon the Company's current expectations, forecasts, and assumptions that are subject to risks, uncertainties, and other factors that could cause actual outcomes and results to differ materially from those indicated by these forward-looking statements. These risks, uncertainties, and other factors include, but are not limited to: the Company's financial results for the quarter ended March 31, 2010 may not necessarily be indicative of future results as future revenues may not meet expectations due to the possible failure of the Company's products to achieve commercial acceptance, changes in customer's needs and technological innovations, and expenses that may be higher than anticipated due to unforeseen costs or cost increases; the risk that the Company may be unable to improve total revenue and PCT products and services revenue, the number of PCT Systems installations, and its operating loss due to unexpected costs or increases in costs and therefore the Company will need additional capital sooner than anticipated; possible difficulties or delays in the implementation of the Company's strategies that may adversely affect the Company's continued commercialization of PCT; the possibility that the Company will not be successful in reaching any additional collaboration agreements with strategic partners in 2010; changes in customer's needs and technological innovations; that other scientists may not be able to corroborate the data generated by third party labs that have been previously reported and that are expected to be presented at the Harvard Symposium on May 21; and the Company's sales force may not be successful in selling the Company's PCT product line because scientists may not perceive the advantages of PCT over other sample preparation methods. Further, the Company expects that it will need additional capital to fund its continuing operations beyond the first quarter of 2011. Additional risks and uncertainties that could cause actual results to differ materially from those indicated by these forward-looking statements are discussed under the heading "Risk Factors" in the Company's Annual Report on Form 10-K for the year ended December 31, 2009, and other reports filed by the Company from time to time with the SEC. The Company undertakes no obligation to update any of the information included in this release, except as otherwise required by law.

       Visit us at our website http://www.pressurebiosciences.com

  Consolidated Statements of
   Operations
  (Unaudited)                     For the Three Months Ended

                                          March 31,
                                 ----------------------------

                                      2010           2009
                                 --------------  ------------

  REVENUE:
   PCT Products, services,
    other                             $ 189,150     $ 222,142

   Grant revenue                        101,663        84,620
                                 --------------  ------------

     Total revenue                      290,813       306,762
                                 --------------  ------------

  COSTS AND EXPENSES:
   Cost of PCT products and
    services                             87,103       140,243
   Research and development             294,141       307,224
   Selling and marketing                282,578       278,416

   General and administrative           538,422       430,790
                                 --------------  ------------
     Total operating costs and
      expenses                        1,202,244     1,156,673
                                 --------------  ------------

     Operating loss                   (911,431)     (849,911)


   Interest income                          106         2,403
                                 --------------  ------------

     Loss before income taxes         (911,325)     (847,508)

     Income tax refund                       --       623,262
                                 --------------  ------------

   Net loss                           (911,325)     (224,246)
                                 --------------  ------------
   Accrued and deemed dividends
    on convertible preferred
    stock                             (256,524)     (501,425)
                                 --------------  ------------
   Net loss applicable to
    common shareholders           $ (1,167,849)   $ (725,671)
                                 ==============  ============


   Net loss per share
    attributable to common
    stockholders - basic and
    diluted                            $ (0.49)      $ (0.33)

   Weighted average common
    stock shares outstanding
    used in the basic
   and diluted net loss per
    share calculation                 2,394,311     2,195,283

  Consolidated Balance Sheets
  (Unaudited)                       March 31,    December 31,

                                       2010          2009
                                   ------------  ------------
               ASSETS
  CURRENT ASSETS
  Cash and cash equivalents         $ 1,617,714   $ 1,609,778
   Restricted cash                       20,012        20,012
   Accounts receivable, net of
    allowances of $17,020 at
    March 31,
   2010 and $8,400 at December
    31, 2009                            217,991       203,211
   Inventories                          576,133       638,350
   Deposits                             344,747       182,010
   Prepaid income taxes                   1,442         3,176
   Prepaid expenses and other
    current assets                       95,981        86,563
                                   ------------  ------------

   Total current assets               2,874,020     2,743,100
                                   ------------  ------------


  PROPERTY AND EQUIPMENT, NET           241,702       249,465
                                   ------------  ------------

  OTHER ASSETS

   Intangible assets, net               218,868       231,026
                                   ------------  ------------

   TOTAL ASSETS                     $ 3,334,590   $ 3,223,591
                                   ============  ============

   LIABILITIES AND STOCKHOLDERS'
               EQUITY
  CURRENT LIABILITIES
   Accounts payable                   $ 426,413     $ 148,087
   Accrued employee compensation        153,327       105,824
   Accrued professional fees and
    other                               217,733       271,926

   Deferred revenue                       5,266         8,058
                                   ------------  ------------

   Total current liabilities            802,739       533,895
                                   ------------  ------------

  LONG TERM LIABILITIES

   Deferred revenue                         986         1,609
                                   ------------  ------------

   TOTAL LIABILITIES                    803,725       535,504
                                   ------------  ------------

  COMMITMENTS AND CONTINGENCIES

  STOCKHOLDERS' EQUITY
   Series A convertible preferred
    stock, $.01 par value;
    313,960 designated shares;
   174,440 shares issued and
    outstanding on March 31, 2010
    and 152,213 shares on
   December 31, 2009 (Liquidation
    value of $2,006,060)                  1,745         1,523
   Series B convertible preferred
    stock, $.01 par value;
    279,256 designated shares;
   88,711 shares issued and
    outstanding on March 31, 2010
    and 62,039 shares on
   December 31, 2009 (Liquidation
    value of $1,667,767)                    887           620
   Common stock, $.01 par value;
    20,000,000 shares authorized;
    2,394,311 shares
   issued and outstanding on
    March 31, 2010 and 2,328,426
    shares issued and
   outstanding on December 31,
    2009                                 23,943        23,284
   Warrants to acquire preferred
    stock and common stock            1,452,878     1,352,165
   Additional paid-in capital        10,153,875     9,297,115

   Accumulated deficit              (9,102,463)   (7,986,620)
                                   ------------  ------------

   Total stockholders' equity         2,530,865     2,688,087
                                   ------------  ------------
   TOTAL LIABILITIES AND
    STOCKHOLDERS' EQUITY            $ 3,334,590   $ 3,223,591
                                   ============  ============

CONTACT:  Pressure BioSciences, Inc.
          Investor Contacts:
          Richard T. Schumacher, President & CEO
          R. Wayne Fritzsche, Chairman
          Joseph L. Damasio, Jr., Controller
          (508) 230-1828