Annual report pursuant to Section 13 and 15(d)

Income Taxes (Details Narrative)

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Income Taxes (Details Narrative) - USD ($)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2018
Operating Loss Carryforwards [Line Items]    
Operating Loss Carryforwards   $ 57,298,328
Domestic Tax Authority [Member]    
Operating Loss Carryforwards [Line Items]    
Operating Loss Carryforwards $ 98,933,918  
Operating loss carry-forwards expire term 2022 through 2037  
Domestic Tax Authority [Member] | Research Tax Credit Carryforward [Member]    
Operating Loss Carryforwards [Line Items]    
Operating loss carry-forwards expire term 2022  
Income Tax Examination, Description Under the Tax Reform Act, NOL’s generated after December 31, 2017 can offset only 80% of a corporation’s taxable income in any year.  
Deferred Tax Assets, Tax Credit Carryforwards $ 1,288,308  
State and Local Jurisdiction [Member]    
Operating Loss Carryforwards [Line Items]    
Operating Loss Carryforwards $ 94,663,553  
Operating loss carry-forwards expire term 2031 through 2038  
State and Local Jurisdiction [Member] | Research Tax Credit Carryforward [Member]    
Operating Loss Carryforwards [Line Items]    
Operating loss carry-forwards expire term 2023 through 2034  
Deferred Tax Assets, Tax Credit Carryforwards $ 306,425