Pressure BioSciences, Inc. Annual report pursuant to Section 13 and 15(d)

Annual report pursuant to Section 13 and 15(d)

Stockholders' Deficit (Details Narrative)

Stockholders' Deficit (Details Narrative) - USD ($)																										1 Months Ended					3 Months Ended	12 Months Ended
Stockholders' Deficit (Details Narrative) - USD ($)	Dec. 12, 2017	Dec. 11, 2017	Sep. 20, 2017	Sep. 12, 2017	Jun. 09, 2017	May 10, 2017	May 02, 2017	Apr. 19, 2017	Mar. 21, 2017	Mar. 14, 2017	Dec. 12, 2016	Jul. 22, 2015	Dec. 23, 2014	Nov. 12, 2014	Jun. 30, 2014	Feb. 28, 2014	Feb. 02, 2014	Jan. 29, 2014	Dec. 12, 2013	Mar. 28, 2013	Feb. 06, 2013	Jan. 04, 2013	Nov. 15, 2012	Jul. 06, 2012	Nov. 11, 2011	Dec. 31, 2017	Jan. 31, 2017	Nov. 30, 2016	Dec. 31, 2013	Apr. 30, 2012	Dec. 31, 2017	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015	Sep. 30, 2017	Aug. 18, 2017	Oct. 28, 2016	Nov. 29, 2015	Sep. 22, 2014	Apr. 04, 2014	Jan. 31, 2014	Dec. 21, 2013	Dec. 28, 2012
Convertible preferred stock, authorized																										1,000,000					1,000,000	1,000,000
Convertible preferred stock, par value																										$ 0.01					$ 0.01	$ 0.01
Convertible preferred stock, shares issued																										1,000,000					1,000,000	1,000,000
Proceeds from warrants issued																																$ 186,802
Number of shares issued to investor, shares				3,333
Shares issued during period, value																																	$ 610,000
Convertible debt balance																										$ 0					$ 0	0
Fair value of warrant																																$ 2,847,624
Common stock, shares outstanding under the plan																										1,147,234					1,147,234	1,147,234	1,057,632	1,159,964
Number of common stock value issued for consulting and investor services																																$ 46,992	$ 332,696
Number of shares issued to debenture holders																																61,307
Gain on extinguishment of debt																																$ 185,452	5,044
Number of restricted stock value	$ 600,000
Percentage of annual interest rates				10.00%
Original issue of discount percentage				35.00%
Number of warrant to purchase common stock																										$ 9,878,513					$ 9,878,513	9,878,513	6,325,102
Debt principal amount												$ 2,180,000														4,093,500					4,093,500	4,093,500
Unamortized debt discount				$ 25,000																						401,856					401,856	$ 401,856	$ 2,235,839
Amortization of interest expenses				13,000
Proceeds from loan				$ 225,000
Debt instrument, maturity date												Mar. 19, 2018
Number of restricted common stock shares issued	150,000		4,000
Privately-held Investment Firm [Member]
Number of shares issued to investor, shares								8,333
Percentage of annual interest rates								10.00%
Original issue of discount percentage								10.00%
Number of shares issued at closing								833
Investor [Member] \| Every Sixty Days [Member]
Number of shares issued to investor, shares								2,500
Debenture Holders [Member]
Number of shares issued to debenture holders																																61,307
Accrued interest																										$ 483,054					$ 483,054	$ 483,054
Gain on extinguishment of debt																																$ 218,452
Noteholders [Member]
Number of shares issued to investor, shares		250,00.
Shares issued during period, value		$ 9,500
Debt principal amount		$ 170,000
Debt instrument, maturity date		Feb. 15, 2018
Minimum [Member]
Percentage of annual interest rates																										5.00%					5.00%	5.00%
Maximum [Member]
Percentage of annual interest rates																										12.00%					12.00%	12.00%
Series G Warrants [Member]
Warrant exercise price																										$ 15.00					$ 15.00	$ 15.00
Common Stock [Member]
Number of shares issued to investor, shares																																	50,834
Shares issued during period, value																																	$ 508
Number of common stock shares issued for services																										2,134						5,667	25,167
Number of common stock value issued for consulting and investor services																																$ 57	$ 252
Number of shares issued to debenture holders																															9,700		14,028
Unamortized debt discount																										$ 37,435					$ 37,435	$ 37,435
Series D Registered Direct Offering [Member]
Warrant exercise price						$ 8.40
Proceeds from warrants issued						$ 140,214
Number of shares issued to investor, shares						19,889
Number of warrants to purchase common stock, shares						39,778
Fair value of warrant						$ 186,802
Value of shares invested in private placements						$ 8,950
2005 Equity Incentive [Member]
Common stock reserved for stock option plan																										1,800,000					1,800,000	1,800,000
Common stock, shares outstanding under the plan																										35,274					35,274	35,274
2013 Equity Incentive Plan [Member]
Common stock reserved for stock option plan																			3,000,000
Common stock, shares outstanding under the plan																			82,481
Common stock, shares available for future grant																			2,917,519
2015 Equity Incentive Plan [Member]
Common stock reserved for stock option plan																																						5,000,000
Common stock, shares outstanding under the plan																																						129,937
Common stock, shares available for future grant																																						4,870,063
Unrecognized compensation cost																																$ 392,590
Compensation cost reorganization period																																1 year 7 months 28 days
Restricted Common Stock [Member]
Number of restricted stock value																																$ 16,000
Restricted Common Stock [Member] \| Administrative Expenses [Member]
Number of restricted stock value																																$ 15,000
Series D Warrant [Member]
Warrant exercise price																										$ 24.30			$ 7.50	$ 12.00	$ 24.30	$ 24.30
Change in number of warrants																													20,958	17,681
Number of warrants issued during period																													55,887	34,930
Series J Warrant [Member]
Warrant exercise price																										12.00					12.00	12.00
Stock issuance price per share																										$ 24.00					$ 24.00	$ 24.00
Series J Warrant [Member] \| Minimum [Member]
Change in number of warrants																																5,000,000
Warrants expiration date																																May 20, 2016
Series K Warrant [Member]
Proceeds from direct offering																	$ 5,000,000
Warrant exercise price														$ 9.38	$ 11.25	$ 12.75		$ 9.38																								$ 9.38
Warrant Derivative Liability [Member]
Proceeds from direct offering																																$ 171,733
Warrant exercise price																																	$ 12.00	$ 12.00
Warrant expiring term																																5 years	5 years	5 years
Aggregate warrant to lenders to purchase common stock shares																																	83,902	292,262
Aggregate warrant to placement agent to purchase common stock shares																																	13,750	56,310
Non-Convertible Loan [Member]
Number of shares issued to investor, shares								8,333
Percentage of annual interest rates								10.00%	10.00%	10.00%
Original issue of discount percentage								10.00%	10.00%	10.00%																									35.00%
Proceeds from loan								$ 250,000		$ 250,000
Non-Convertible Loan [Member] \| Privately-held Investment Firm [Member]
Proceeds from non convertible debt								$ 250,000
Non-Convertible Loan [Member] \| Investor [Member]
Convertible debt balance																										$ 0					$ 0	$ 0
Original issue of discount percentage																										35.00%					35.00%	35.00%
Unamortized debt discount																										$ 12,420					$ 12,420	$ 12,420
Non-Convertible Loan [Member] \| Investor [Member]
Convertible debt balance																										$ 170,000					$ 170,000	$ 170,000
Number of shares issued to debenture holders																																9,500
Original issue of discount percentage																										35.00%					35.00%	35.00%
Unamortized debt discount																										$ 7,238					$ 7,238	$ 7,238
Number of restricted common stock shares issued									5,667	8,333
Revolving Note [Member]
Warrant exercise price							$ 12.00
Number of warrants to purchase common stock, shares							16,667
Fair value of warrant																																$ 291,667
Number of warrant to purchase common stock							$ 3,000,000
Debt principal amount																																				$ 3,500,000
Revolving Note [Member] \| Investor [Member]
Warrant exercise price							$ 12.00																														$ 12.00
Number of shares issued to investor, shares							16,667
Shares issued during period, value							$ 149,018
Number of warrants to purchase common stock, shares																																					20,834
Revolving Note [Member] \| Maximum [Member] \| Investor [Member]
Warrant exercise price																																					$ 12.00
Number of warrants to purchase common stock, shares																																					291,667
Series A Junior Participating Preferred Stock [Member]
Number of stock designated																										20,000					20,000	20,000
Series A Convertible Preferred Stock [Member]
Number of stock designated																										313,960					313,960	313,960
Series B Convertible Preferred Stock [Member]
Number of stock designated																										279,256					279,256	279,256
Series C Convertible Preferred Stock [Member]
Number of stock designated																										88,098					88,098	88,098
Series D Convertible Preferred Stock [Member]
Convertible preferred stock, authorized																										850					850	850	850
Convertible preferred stock, par value																									$ 0.01	$ 0.01					$ 0.01	$ 0.01	$ .01
Convertible preferred stock, shares issued																										300					300	300	300
Number of stock designated																										850					850	850
Aggregate number of units sold																									843
Purchase price per units sold																									$ 1,000
Proceeds from direct offering																									$ 843,000
Warrant exercise price																									$ 24.30
Issuance of warrants to purchase of common stock shares																									21
Conversion of stock into shares																									84
Additional paid in capital and accumulated deficit																																$ 530,140
Adjustment to additional paid in capital related to the beneficial conversion feature																																530,140
Amount to be paid at any uncertain situation value per share (subject to accrued but unpaid dividends)																										$ 1,000					$ 1,000	$ 1,000
Change in exercise price of warrants																										$ 19.50					$ 19.50	$ 19.50
Convertible preferred stock, conversion percentage																																300.00%
Average daily trading volume																																50,000
Ownership, percentage																										50.00%					50.00%	50.00%
Preferred stock value issued																										$ 3					$ 3	$ 3	$ 3
Series D Convertible Preferred Stock [Member] \| Series D Warrant [Member]
Proceeds from warrants issued																																283,725
Proceeds from convertible preferred stock																																$ 559,275
Series E Convertible Preferred Stock [Member]
Number of stock designated																										500					500	500
Series G Convertible Preferred Stock [Member]
Convertible preferred stock, authorized																										240,000					240,000	240,000	240,000
Convertible preferred stock, par value																							$ 0.01	$ 0.01		$ 0.01					$ 0.01	$ 0.01	$ 0.01
Convertible preferred stock, shares issued																										80,570					80,570	80,570	86,570
Number of stock designated																										240,000					240,000	240,000
Aggregate number of units sold																							4,844	4,844
Purchase price per units sold																							$ 150.00	$ 150.00
Proceeds from direct offering																							$ 726,600	$ 726,600
Warrant exercise price																										$ 15.00					$ 15.00	$ 15.00
Issuance of warrants to purchase of common stock shares																																5
Conversion of stock into shares					2,000
Convertible preferred stock, conversion percentage																																12.00%
Value of shares invested in private placements																																$ 726,600
Warrant expiring term																								3 years
Cumulative dividend rate percentage																																4.00%
Percentage of shares purchased for investment																																6.00%
Preferred stock value issued																										$ 806					$ 806	$ 806	$ 866
Stock issuance price per share																										$ 22.50					$ 22.50	$ 22.50
Conversion of stock					6,000
Series G Convertible Preferred Stock [Member] \| Minimum [Member]
Proceeds from direct offering																																$ 2,500,000
Average daily trading volume																																334
Value of shares invested in private placements																																$ 250,000
Preferred stock value issued																										$ 100,000					$ 100,000	100,000
Series G Convertible Preferred Stock [Member] \| Maximum [Member]
Preferred stock value issued																										$ 250,000					$ 250,000	$ 250,000
Series H Convertible Preferred Stock [Member]
Convertible preferred stock, authorized																										10,000					10,000	10,000	10,000										10,000
Convertible preferred stock, par value																						$ 0.01				$ 0.01					$ 0.01	$ 0.01	$ 0.01
Convertible preferred stock, shares issued																										10,000					10,000	10,000	10,000
Number of stock designated																										10,000					10,000	10,000
Purchase price per units sold																						$ 24.08
Issuance of warrants to purchase of common stock shares																						4
Preferred stock value issued																										$ 100					$ 100	$ 100	$ 100										$ 100,000
Number of common shares exchanged																						33,334
Series H2 Convertible Preferred Stock [Member]
Convertible preferred stock, authorized																										21					21	21	21
Convertible preferred stock, par value													$ 0.01													$ 0.01					$ 0.01	$ 0.01	$ 0.01
Convertible preferred stock, shares issued													21													21					21	21	21
Number of stock designated																										21					21	21
Purchase price per units sold													$ 7.50
Issuance of warrants to purchase of common stock shares													3,334
Preferred stock value issued
Number of common shares exchanged													70,000
Series J Convertible Preferred Stock [Member]
Convertible preferred stock, authorized																										6,250					6,250	6,250	6,250
Convertible preferred stock, par value																				$ 0.01	$ 0.01					$ 0.01					$ 0.01	$ 0.01	$ 0.01
Convertible preferred stock, shares issued																										3,458					3,458	3,458	3,521
Number of stock designated																										6,250					6,250	6,250
Aggregate number of units sold																				5,087.5	5,087.5
Purchase price per units sold																				$ 400.00	$ 400.00
Proceeds from direct offering																				$ 2,034,700	$ 2,034,700
Warrant exercise price																				$ 12.00	$ 12.00
Conversion of stock into shares					2,100
Value of shares invested in private placements																					$ 250,000
Preferred stock value issued																					$ 250,000					$ 35					$ 35	$ 35	$ 35
Stock issuance price per share																										$ 24.00					$ 24.00	$ 24.00
Conversion of stock					63															34	34
Series J Convertible Preferred Stock [Member] \| Minimum [Member]
Average daily trading volume																																1,667
Value of shares invested in private placements																																$ 2,500,000
Series K Convertible Preferred Stock [Member]
Convertible preferred stock, authorized																										15,000					15,000	15,000	15,000
Convertible preferred stock, par value														$ 0.01	$ 0.01	$ 0.01		$ 0.01	$ 0.10							$ 0.01					$ 0.01	$ 0.01	$ 0.01
Convertible preferred stock, shares issued														34	34	34		34								6,880					6,880	6,880	6,816						2,134
Number of stock designated																										15,000					15,000	15,000
Aggregate number of units sold														1,052	734	1,854		4,875	4,000
Purchase price per units sold														$ 250.00	$ 300.00	$ 340.00		$ 250.00	$ 250.00
Proceeds from direct offering														$ 263,000	$ 220,000	$ 630,360		$ 1,218,750	$ 1,000,000													$ 100,000
Warrant exercise price														$ 9.38	$ 11.25	$ 12.75										$ 9.38					$ 9.38	$ 9.38
Issuance of warrants to purchase of common stock shares														17	17	17		17														34
Proceeds from warrants issued																																$ 271,422
Proceeds from convertible preferred stock																																685,245
Adjustment to additional paid in capital related to the beneficial conversion feature																																$ 1,495,415
Convertible preferred stock, conversion percentage																																4.00%
Average daily trading volume																																1,667
Number of warrants issued during period																																17
Value of shares invested in private placements														$ 3,332,110																		$ 1,000,000
Preferred stock value issued																										$ 68					$ 68	$ 68	$ 68
Stock issuance price per share																										$ 24.00					$ 24.00	$ 24.00
Warrants expiration date														Nov. 12, 2017	Jun. 30, 2017	Feb. 28, 2017		Jan. 29, 2017
Cash received in private placement														$ 2,511,404																		$ 572,044
Fee incurred with private placement																																$ 43,334
Percentage of stock acquired																																6.00%
Conversion of outstanding indebtedness and accrued board of directors' fees														820,706												$ 427,956					$ 427,956	$ 427,956
Increase in subscription amount																$ 3,500,000		$ 718,750
Number of shares returned																										64					64	64
Number of common stock shares issued for services																																2,134
Number of common stock value issued for consulting and investor services																																$ 15,992
Series K Convertible Preferred Stock [Member] \| Tranche Two [Member]
Proceeds from direct offering																		$ 1,500,000
Increase in subscription amount																																									$ 1,218,750
Series K Convertible Preferred Stock [Member] \| Tranche Third [Member]
Proceeds from direct offering																1,500,000
Increase in subscription amount																$ 630,360
Series K Convertible Preferred Stock [Member] \| Fourth Tranche [Member]
Proceeds from direct offering															$ 1,500,000
Increase in subscription amount															$ 220,000
Series K Convertible Preferred Stock [Member] \| Fifth Tranche [Member]
Proceeds from direct offering														1,500,000
Increase in subscription amount														$ 263,000
Series K Convertible Preferred Stock [Member] \| Initial Tranche [Member]
Increase in subscription amount																			$ 1,000,000
Series K Convertible Preferred Stock [Member] \| Minimum [Member]
Proceeds from direct offering											$ 2,500,000
Increase in subscription amount																																								$ 4,500,000
Series K Convertible Preferred Stock [Member] \| Maximum [Member]
Increase in subscription amount																																								$ 1,000,000
Restricted Common Stock [Member] \| Investor [Member]
Number of common stock shares issued for services																											3,334	11,000
Number of common stock value issued for consulting and investor services																											$ 15,558	$ 84,735