Pressure BioSciences, Inc. Annual report pursuant to Section 13 and 15(d)

Annual report pursuant to Section 13 and 15(d)

Stockholders' (Deficit) (Details Narrative)

Stockholders' (Deficit) (Details Narrative) - USD ($)																		1 Months Ended		3 Months Ended		9 Months Ended	12 Months Ended
Stockholders' (Deficit) (Details Narrative) - USD ($)	Dec. 31, 2018	Nov. 05, 2018	Jul. 18, 2018	Jun. 11, 2018	Jun. 02, 2018	May 14, 2018	May 02, 2018	May 02, 2018	May 10, 2017	Dec. 23, 2014	May 30, 2013	Mar. 28, 2013	Feb. 06, 2013	Jan. 04, 2013	Nov. 05, 2012	Jul. 06, 2012	Nov. 11, 2011	Dec. 31, 2013	Apr. 30, 2012	Dec. 31, 2018	Dec. 31, 2018	Sep. 30, 2018	Dec. 31, 2018	Dec. 31, 2017	Mar. 12, 2018	Dec. 31, 2016	Nov. 29, 2015	Dec. 12, 2013	Dec. 28, 2012
Convertible preferred stock, authorized	1,000,000																			1,000,000	1,000,000		1,000,000	1,000,000
Convertible preferred stock, par value	$ 0.01																			$ 0.01	$ 0.01		$ 0.01	$ 0.01
Convertible preferred stock, shares issued	1,000,000																			1,000,000	1,000,000		1,000,000	1,000,000
Warrants term				5 years
Warrant to purchase shares of common stock				110,833
Warrant exercise price per share				$ 3.50
Proceeds from convertible preferred stock																							$ 2,824,664
Warrants outstanding	$ 19,807,247																			$ 19,807,247	$ 19,807,247		19,807,247	9,878,513
Proceeds from exercises of warrants																								140,214
Number of common stock value issued for consulting and investor services																							$ 238,120	$ 46,992
Common stock, par value	$ 0.01																			$ 0.01	$ 0.01		$ 0.01	$ 0.01
Debt converted principal amount																							$ 12,688,635
Debt conversion price per share	$ 7.50																			$ 7.50	$ 7.50		$ 7.50
Adjusted value of beneficial conversion feature																							$ 12,881,899
Common stock, shares outstanding under the plan	8,131,555																			8,131,555	8,131,555		8,131,555	1,147,234		1,057,631
Outstanding stock options, terminated																							455,092	11,946
New stock options, exercise price	$ 3.40																			$ 3.40	$ 3.40		$ 3.40
Stock options issued																							7,452,416	332,859
Issuance of stock options																							$ 759,469
Total unrecognized compensation cost	$ 801,885																			$ 801,885	$ 801,885		$ 801,885
Unvested stock options weighted average period																							1 year 1 month 24 days
Aggregate intrinsic value of options outstanding and exercisable	$ 0																			$ 0	$ 0		$ 0
Fair value recorded as other charges				$ 340,257
Warrant exercise price increase				$ 15.00
Warrant exercise price decrease				$ 3.50
Modification of debt				$ 10,236
Number of shares issued, value
Convertible Loans One [Member]
Number of common stock shares issued, shares																							64,652
Number of shares issued, value																							$ 220,952
Convertible Loans Two [Member]
Number of common stock shares issued, shares																							88,311
Number of shares issued, value																							$ 288,648
Current Officers, Employees and Board Members [Member]
New stock options, exercise price			$ 3.40
Board Members [Member]
Stock options, vesting period			12 months
Debt maturity date			Jul. 18, 2028
Current Officers and Employees [Member]
Stock options, vesting period			36 months
Officers, Employees and Board [Member]
New stock options, exercise price		$ 3.40
Stock options issued		25,000
Officers, Employees and Board [Member] \| Black Scholes Method [Member]
New stock options, exercise price		$ 3.07
Accredited Investor [Member]
Number of restricted stock issued																							341,324
Number of restricted stock issued during period, value																							$ 1,005,941
Investor [Member]
Warrant to purchase shares of common stock				29,167
Letter Agreement [Member]
Debt converted principal amount				$ 742,134
Debt converted of shares				296.80
Terminated and Reissues [Member] \| Current Officers, Employees and Board Members [Member]
Outstanding stock options, terminated			244,467
Letter Agreements [Member] \| Accredited Investor [Member]
Number of common stock shares issued, shares				110,833
Minimum [Member] \| Letter Agreement [Member]
Warrant exercise price per share				$ 3.50
Maximum [Member] \| Letter Agreement [Member]
Warrant exercise price per share				$ 12.00
Series D Registered Direct Offering [Member]
Warrant to purchase shares of common stock									39,778
Warrant exercise price per share									$ 8.40
Proceeds from warrants issued									$ 140,214
Proceeds from exercises of warrants									$ 140,214
Number of warrants exercised									19,889
Fair value of warrant									$ 186,802
Number of common stock shares issued, shares									19,889
2005 Equity Incentive Plan [Member]
Common stock reserved for stock option plan	1,800,000																			1,800,000	1,800,000		1,800,000
Other Plans [Member]
Common stock, shares outstanding under the plan	32,605																			32,605	32,605		32,605
Other Plans [Member] \| Terminated and Reissues [Member]
Outstanding stock options, terminated	32,605
Stock options issued	32,605
2013 Equity Incentive Plan [Member]
Common stock reserved for stock option plan	633,266																			633,266	633,266		633,266					3,000,000
Common stock, shares outstanding under the plan	366,734																			366,734	366,734		366,734
Stock options issued	51,934
Number of shares awarded																												2,917,519
2013 Equity Incentive Plan [Member] \| Terminated and Reissues [Member]
Outstanding stock options, terminated	81,925
Stock options issued	16,641
Reissuance of stock options	81,925
2015 Nonqualified Stock Option Plan [Member]
Common stock reserved for stock option plan																											5,000,000
Stock options issued	49,333	203,734
Unamortized expense		$ 108,400
2015 Nonqualified Stock Option Plan [Member] \| Terminated and Reissues [Member]
Outstanding stock options, terminated	129,937
Stock options issued	15,964
Reissuance of stock options	129,937
Series D Warrants [Member]
Warrant exercise price per share	$ 24.30																			$ 24.30	$ 24.30		$ 24.30
New Warrant [Member] \| Securities Purchase Agreement [Member]
Warrant to purchase shares of common stock					20,000		100,000	100,000
Warrant exercise price per share					$ 3.50		$ 3.50	$ 3.50
New Warrant [Member] \| Letter Agreement [Member]
Warrant to purchase shares of common stock				296,800		2,448,200
Warrant exercise price per share				$ 3.50		$ 3.50
New Warrant [Member] \| Letter Agreement [Member] \| Investor [Member]
Warrant exercise price per share				$ 3.50
Issuance of warrants to purchase of common stock shares				2,200,000
New Warrant [Member] \| Letter Agreements [Member]
Warrant exercise price per share						3.50
Warrant [Member]
Common stock, shares outstanding under the plan	7,764,821																			7,764,821	7,764,821		7,764,821	899,542		881,989
Outstanding stock options, terminated
Stock options issued																							6,877,948	245,661
Warrant [Member] \| Securities Purchase Agreement [Member]
Warrant to purchase shares of common stock	695,000																			695,000	695,000	460,000	695,000
Warrant exercise price per share	$ 3.50																			$ 3.50	$ 3.50	$ 3.50	$ 3.50
Warrants outstanding	$ 277,277																			$ 277,277	$ 277,277		$ 277,277
Issuance of warrants to purchase of common stock shares	148,160																			148,160	148,160		148,160
Warrant [Member] \| Letter Agreement [Member]
Warrant exercise price per share				$ 3.50		$ 3.50
Warrants [Member]
Fair value of warrant																							$ 9,928,734
Number of warrants shares issued	6,877,728																			6,877,728	6,877,728		6,877,728
Warrants [Member] \| Securities Purchase Agreement [Member]
Warrant to purchase shares of common stock							100,000	100,000
Warrant exercise price per share							$ 3.50	$ 3.50
Broker Warrants [Member]
Number of warrants shares issued	274,660																			274,660	274,660		274,660
Series A Junior Participating Preferred Stock [Member]
Convertible preferred stock, shares issued
Number of stock designated	20,000																			20,000	20,000		20,000
Preferred stock, shares outstanding
Series A Convertible Preferred Stock [Member]
Convertible preferred stock, shares issued
Number of stock designated	313,960																			313,960	313,960		313,960
Preferred stock, shares outstanding
Series B Convertible Preferred Stock [Member]
Convertible preferred stock, shares issued
Number of stock designated	279,256																			279,256	279,256		279,256
Preferred stock, shares outstanding
Series C Convertible Preferred Stock [Member]
Convertible preferred stock, shares issued
Number of stock designated	88,098																			88,098	88,098		88,098
Preferred stock, shares outstanding
Series D Convertible Preferred Stock [Member]
Convertible preferred stock, authorized	850																			850	850		850	850
Convertible preferred stock, par value	$ 0.01																$ 0.01			$ 0.01	$ 0.01		$ 0.01	$ 0.01
Convertible preferred stock, shares issued	300																			300	300		300	300
Number of stock designated	850																			850	850		850
Preferred stock, shares outstanding	300																			300	300		300	300
Sale of stock																	843
Purchase price per units sold																	$ 1,000
Proceeds from direct offering																	$ 843,000
Warrants term																	5 years
Warrant to purchase shares of common stock																	21
Warrant exercise price per share																	$ 24.30	$ 7.50	$ 12.00
Warrants exercisable date																	May 11, 2012
Amount to be paid at any uncertain situation value per share (subject to accrued but unpaid dividends)	$ 1,000																			$ 1,000	$ 1,000		$ 1,000
Conversion of stock into shares																	84
Stock conversion price per share																							$ 19.50
Convertible preferred stock, conversion percentage																							300.00%
Average daily trading volume																							50,000
Ownership percentage	50.00%																			50.00%	50.00%		50.00%
Change in number of warrants																		20,958	17,681
Warrants outstanding																		$ 55,887	$ 34,930
Series E Convertible Preferred Stock [Member]
Number of stock designated	500																			500	500		500
Series G Convertible Preferred Stock [Member]
Convertible preferred stock, authorized	240,000																			240,000	240,000		240,000	240,000
Convertible preferred stock, par value	$ 0.01														$ 0.01	$ 0.01				$ 0.01	$ 0.01		$ 0.01	$ 0.01
Convertible preferred stock, shares issued	80,570																			80,570	80,570		80,570	80,570
Number of stock designated	240,000																			240,000	240,000		240,000
Preferred stock, shares outstanding	80,570																			80,570	80,570		80,570	80,570
Sale of stock															4,844	4,844
Purchase price per units sold															$ 150.00	$ 150.00
Proceeds from direct offering															$ 726,600	$ 726,600
Warrants term															3 years	3 years
Warrant to purchase shares of common stock															1	1
Warrant exercise price per share															$ 15.00	$ 15.00
Convertible preferred stock, conversion percentage																							12.00%
Number of common stock shares issued, shares															1	1
Cumulative dividend rate percentage																							4.00%
Percentage of shares purchased for investment																							6.00%
Series G Convertible Preferred Stock [Member] \| Minimum [Member]
Purchase price per units sold	$ 22.50																			$ 22.50	$ 22.50		$ 22.50
Proceeds from direct offering																							$ 2,500,000
Average daily trading volume																							334
Number of preferred stock issued upon conversion	100,000																			100,000	100,000		100,000
Series G Convertible Preferred Stock [Member] \| Maximum [Member]
Number of preferred stock issued upon conversion	250,000																			250,000	250,000		250,000
Series H Convertible Preferred Stock [Member]
Convertible preferred stock, authorized	10,000																			10,000	10,000		10,000	10,000					10,000
Convertible preferred stock, par value	$ 0.01													$ 0.01						$ 0.01	$ 0.01		$ 0.01	$ 0.01
Convertible preferred stock, shares issued	10,000																			10,000	10,000		10,000	10,000
Number of stock designated	10,000													10,000						10,000	10,000		10,000
Preferred stock, shares outstanding	10,000																			10,000	10,000		10,000	10,000
Purchase price per units sold														$ 24.08
Conversion of stock into shares														4
Number of common shares exchanged														33,334
Common stock, par value														$ 0.01
Series H2 Convertible Preferred Stock [Member]
Convertible preferred stock, authorized	21									21										21	21		21	21
Convertible preferred stock, par value	$ 0.01									$ 0.01										$ 0.01	$ 0.01		$ 0.01	$ 0.01
Convertible preferred stock, shares issued	21									21										21	21		21	21
Number of stock designated	21									21										21	21		21
Preferred stock, shares outstanding	21																			21	21		21	21
Purchase price per units sold										$ 7.50
Conversion of stock into shares										3,334
Number of common shares exchanged										70,000
Common stock, par value										$ 0.01
Series J Convertible Preferred Stock [Member]
Convertible preferred stock, authorized	6,250																			6,250	6,250		6,250	6,250
Convertible preferred stock, par value	$ 0.01										$ 0.01	$ 0.01	$ 0.01							$ 0.01	$ 0.01		$ 0.01	$ 0.01
Convertible preferred stock, shares issued	3,458																			3,458	3,458		3,458	3,458
Number of stock designated	6,250																			6,250	6,250		6,250
Preferred stock, shares outstanding	3,458																			3,458	3,458		3,458	3,458
Sale of stock											5,087.5	5,087.5	5,087.5
Purchase price per units sold	$ 24.00										$ 400.00	$ 400.00	$ 400.00							$ 24.00	$ 24.00		$ 24.00
Proceeds from direct offering											$ 2,034,700	$ 2,034,700	$ 2,034,700
Warrant to purchase shares of common stock											34	34	34
Warrant exercise price per share											$ 12.00	$ 12.00	$ 12.00
Proceeds from convertible preferred stock																							$ 250,000
Conversion of stock into shares											34	34	34										34
Average daily trading volume																							1,667
Number of shares issued upon conversion												34	34
Series K Convertible Preferred Stock [Member]
Convertible preferred stock, authorized	15,000																			15,000	15,000		15,000	15,000
Convertible preferred stock, par value	$ 0.01																			$ 0.01	$ 0.01		$ 0.01	$ 0.01
Convertible preferred stock, shares issued	6,880																			6,880	6,880		6,880	6,880
Number of stock designated	15,000																			15,000	15,000		15,000
Preferred stock, shares outstanding	6,880																			6,880	6,880		6,880	6,880
Purchase price per units sold	$ 24.00																			$ 24.00	$ 24.00		$ 24.00
Proceeds from direct offering																							$ 2,500,000
Conversion of stock into shares																							34
Average daily trading volume																							1,667
Value of shares invested in private placements																							$ 100,000
Series AA Convertible Preferred Stock [Member]
Convertible preferred stock, authorized	10,000																			10,000	10,000		10,000	10,000
Convertible preferred stock, par value	$ 0.01																			$ 0.01	$ 0.01		$ 0.01	$ 0.01
Convertible preferred stock, shares issued	6,499																			6,499	6,499		6,499	0
Number of stock designated	10,000																			10,000	10,000		10,000
Preferred stock, shares outstanding	6,499																			6,499	6,499		6,499	0
Conversion of stock into shares																							44
Number of common stock shares issued, shares																							76,361
Number of common stock shares issued for services																							68,000
Number of common stock value issued for consulting and investor services																							$ 238,120
Debt converted principal amount																							$ 12,688,634
Debt converted of shares																							5,075.40
Debt conversion price per share																									$ 2.50
Number of shares issued, value																							$ 258,211
Series AA Convertible Preferred Stock [Member] \| Securities Purchase Agreement [Member]
Convertible preferred stock, par value							$ 0.01	$ 0.01
Sale of stock							100	100
Cumulative dividend rate percentage																							8.00%
Number of preferred stock issued upon conversion							1,000	1,000
Sale of stock, amount							$ 250,000	$ 250,000
Series AA Convertible Preferred Stock [Member] \| Securities Purchase Agreement [Member] \| Accredited Investor [Member]
Convertible preferred stock, par value	$ 0.01																			$ 0.01	$ 0.01	$ 0.01	$ 0.01
Sale of stock					20															695		460
Number of preferred stock issued upon conversion	1,000																			1,000	1,000	1,000	1,000
Sale of stock, amount					$ 50,000															$ 1,738,000		$ 1,150,000
Series AA Convertible Preferred Stock [Member] \| Securities Purchase Agreement [Member] \| Two Investor [Member]
Warrant to purchase shares of common stock	82,333																			82,333	82,333		82,333
Proceeds from warrants issued																					$ 358,932
Conversion of stock into shares																					83
Series AA Convertible Preferred Stock [Member] \| Letter Agreement [Member]
Proceeds from warrants issued				$ 10,236
Debt converted principal amount						$ 6,220,500
Debt converted of shares				2,200		2,448.20
Debt conversion price per share				$ 2.50		$ 2.50
Fair value recorded as other charges				$ 312,637
Warrant exercise price increase				$ 15.00
Warrant exercise price decrease				$ 3.50
Number of warrants held by Investor				29,167
Series AA Convertible Preferred Stock [Member] \| Letter Agreement [Member] \| Accredited Investor [Member]
Convertible preferred stock, par value				$ 2,500
Warrants term				5 years
Warrant exercise price per share				$ 3.50
Number of warrants exercised				110,833
Number of common stock shares issued, shares				110.8
Fair value recorded as other charges				$ 340,257
Series AA Convertible Preferred Stock [Member] \| Letter Agreements [Member]
Debt converted of shares						2,448.20
Debt conversion price per share						$ 2.50
Series AA Preferred Stock with Warrants [Member] \| Loan Agreements [Member]
Deemed dividend additional paid in capital	$ 5,113																			$ 5,113	$ 5,113		$ 5,113
Series AA Units [Member]
Reduction in exercise price amount								$ 207,899