EXHIBIT 99.1

FOR IMMEDIATE RELEASE   
 
Investor Contacts:
  
Richard T. Schumacher, President & CEO
PressureBioSciences, Inc.
Edward H. Myles, Vice President of Finance & CFO
(T) 508-580-1818

Pressure BioSciences, Inc. Reports Third Quarter Financial Results

WEST BRIDGEWATER, Mass., November 13, 2006 - Pressure BioSciences, Inc. (NASDAQ: PBIO) today announced that revenue for the three months ended September 30, 2006 was $92,211 as compared to $11,742 for the three months ended September 30, 2005. This increase in revenue was driven by the sales of three PCT Sample Preparation Systems (PCT SPS) during the third quarter of 2006 (to Johns Hopkins University, the National Institutes of Health, and a state laboratory in Virginia). The Company incurred an operating loss from continuing operations of $829,835 in the third quarter of 2006, as compared to an operating loss from continuing operations of $538,902 in the same period of 2005. This increase in operating loss was the result of significant investments made in the Company’s research and development and sales and marketing functions during 2006.

For the nine months ended September 30, 2006, revenue was $174,409 as compared to $21,984 for the nine months ended September 30, 2005. This increase in revenue was driven by the sales of five PCT Sample Preparation Systems during the first nine months of 2006 as compared to no PCT SPS sales during the same period in 2005. The Company incurred an operating loss from continuing operations of $2,987,098 during the first nine months of 2006, compared to an operating loss from continuing operations of $1,868,563 during the same period of 2005. The operating loss for 2006 includes $543,220 of non-cash, stock-based compensation charges incurred as per the provisions of Statement of Financial Accounting Standards Board Statement 123R “Share-Based Payment”. This increase in operating loss was also the result of increased investments in all major areas of the Company’s business, particularly research and development and sales and marketing. Consistent with its business strategy, the Company expects to continue to increase investments in all functional areas of its business in order to support the full commercialization of its novel and patented Pressure Cycling Technology (PCT).

As of September 30, 2006, the Company had cash and cash equivalents of approximately $5.9 million, total working capital of approximately $6.4 million, and marketable securities of approximately $2.5 million. Edward H. Myles, Vice President of Finance and CFO commented: “We are pleased to have made such significant and successful strides down the path towards full PCT commercialization, while concomitantly being able to closely manage our important financial resources.”

Richard T. Schumacher, Founder, President, and CEO commented: “We continue to make significant progress in many areas of our business plan. In addition to filling key positions within our senior management team, building our R&D and marketing capabilities, and making measured progress in the development of new PCT-related products, we have also realized significant success in expanding our collaboration program with key scientific and industry leaders nationwide. We are extremely pleased that some of our collaborators have purchased the PCT Sample Preparation System following their evaluation, while others have published or presented data citing the clear benefits of PCT. We appreciate the work that our nearly 30 collaborators have done to date, and look forward to continuing to work with them as we build interest in this very important, enabling technology.”


About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (PBI) is a publicly traded, early-stage company focused on the development of a novel, enabling technology called Pressure Cycling Technology (PCT). PCT uses cycles of hydrostatic pressure between ambient and ultra-high levels (up to 35,000 psi and greater) to control bio-molecular interactions. PBI currently holds 13 US and 5 foreign patents covering multiple applications of PCT in the life sciences field, including such areas as genomic and proteomic sample preparation, pathogen inactivation, the control of enzymes, immunodiagnostics, and protein purification.

Forward Looking Statements

Statements contained in this press release regarding the Company’s intentions, hopes, beliefs, expectations, or predictions of the future are "forward-looking'' statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements are based upon the Company’s current expectations, forecasts, and assumptions that are subject to risks, uncertainties, and other factors that could cause actual outcomes and results to differ materially from those indicated by these forward-looking statements. These risks, uncertainties, and other factors include, but are not limited to: possible difficulties or delays in the implementation of the Company’s strategies that may adversely affect the Company’s continued commercialization of its PCT Sample Preparation System; the Company’s financial results for the three and nine months ended September 30, 2006 may not necessarily be indicative of future results as future revenues may not meet expectations due to changes in customers needs and technological innovations, and expenses may be higher than anticipated due to unforeseen cost increases; the Company’s collaboration programs may not continue to be successful and may not result in the sale of additional PCT Systems to collaborators or others; and the Company may be unable to develop any new PCT-related products that achieve commercial acceptance. Additional risks and uncertainties that could cause actual results to differ materially from those indicated by these forward-looking statements are discussed under the heading "Risk Factors" in the Company’s Quarterly Report on Form 10-QSB for the quarter ended September 30, 2006, in the Company’s Annual Report on Form 10-KSB, as amended, for the year ended December 31, 2005, and other reports filed by the Company from time to time with the SEC. The Company undertakes no obligation to update any of the information included in this release, except as otherwise required by law.

Visit us at our website http://www.pressurebiosciences.com
 
 
Consolidated Statements of Operations (Unaudited)

   
For the Three Months Ended
  
For the Nine Months Ended 
  
   
September 30, 
  
September 30, 
  
   
2006
  
2005
  
2006
  
2005
  
       
(restated)
      
(restated)
  
REVENUE:
                          
PCT Products, services, other 
  
$
92,211
  
$
11,742
  
$
174,409
  
$
21,984
  
Total revenue
    
92,211
   
11,742
   
174,409
   
21,984
 
                           
COSTS AND EXPENSES:
                          
Cost of PCT products & services 
    
90,037
   
33,966
   
188,688
   
61,653
 
Research and development 
    
324,525
   
156,529
   
984,844
   
374,147
 
Selling and marketing 
    
127,419
   
39,954
   
322,803
   
93,590
 
General and administrative 
    
380,065
   
320,195
   
1,665,172
   
1,361,157
 
Total operating costs and expenses
    
922,046
   
550,644
   
3,161,507
   
1,890,547
 
                           
Operating loss from continuing operations
    
(829,835
)
  
(538,902
)
  
(2,987,098
)
  
(1,868,563
)
                           
OTHER INCOME (EXPENSE):
                          
Realized gain on securities held for sale 
    
-
   
2,838,491
   
517,938
   
2,838,491
 
Other operating, net  
    
-
   
(140,648
)
  
-
   
(528,285
)
Interest income 
    
88,190
   
62,699
   
305,982
   
187,559
 
Total other income
   
88,190
   
2,760,542
   
823,920
   
2,497,765
 
                           
(Loss) income from continuing operations before income taxes
    
(741,645
)
  
2,221,640
   
(2,163,178
)
  
629,202
 
Income tax benefit (provision) from continuing operations
    
111,106
   
(912,671
)
  
408,344
   
(457,535
)
                           
(Loss) income from continuing operations
   
(630,539
)
  
1,308,969
   
(1,754,834
)
  
171,667
 
                           
Discontinued operations:
                          
                         
(Loss) income from discontinued operations (net of income tax benefit of $1,720 and provision of $913 for the three and nine months ended in 2005) 
    
-
   
(3,340
)
  
-
   
1,995
 
                         
Gain on sale of net assets related to discontinued operations (includes effect of income taxes of $701,699 in 2005) 
    
-
   
701,699
   
-
   
701,699
 
                           
Net income from discontinued operations
    
-
   
698,359
   
-
   
703,694
 
                           
Net (loss) income
  
$
(630,539
)
$
2,007,328
  
$
(1,754,834
)
$
875,361
  
                           
(Loss) income per share from continuing operations - basic 
  
$
(0.26
)
$
0.54
  
$
(0.72
)
$
0.05
  
Income per share from discontined operations - basic  
  
$
-
  
$
0.29
  
$
-
  
$
0.23
  
Net (loss) income per share, basic 
  
$
(0.26
)
$
0.83
  
$
(0.72
)
$
0.28
  
                           
(Loss) income per share from continuing operations - diluted 
  
$
(0.26
)
$
0.52
  
$
(0.72
)
$
0.05
  
Income per share from discontined operations - diluted 
  
$
-
  
$
0.27
  
$
-
  
$
0.22
  
Net (loss) income per share, diluted 
  
$
(0.26
)
$
0.79
  
$
(0.72
)
$
0.27
  
                           
Weighted average number of shares used to calculate net (loss) income per share - basic
    
2,422,675
    
2,424,189
    
2,424,351
    
3,157,495
  
                           
Weighted average number of shares used to calculate net (loss) income per share - diluted
    
2,422,675
    
2,537,987
    
2,424,351
    
3,202,101
  
 
 
Condensed Consolidated Balance Sheet Data
 
   
September 30,
  
December 31,
  
   
2006
  
2005
  
   
(unaudited)
  
(restated)
  
           
ASSETS
              
Cash and cash equivalents
 
$
5,850,427
  
$
6,416,772
  
Escrow deposit related to sale of assets to SeraCare
    
-
   
1,117,305
 
Income tax receivable
   
781,457
   
531,122
 
Prepaid expenses, deposits, and other current assets
    
410,933
   
476,436
 
Total current assets
    
7,042,817
   
8,541,635
 
               
PROPERTY AND EQUIPMENT, NET
    
200,146
   
282,780
 
               
Intangible assets, net
    
389,080
   
425,554
 
Assets transferred under contractual arrangements
    
1,420,996
   
1,420,996
 
Investments in marketable securities
    
2,549,113
   
3,962,810
 
Total other assets
    
4,359,189
   
5,809,360
 
               
TOTAL ASSETS
  
$
11,602,152
  
$
14,633,775
  
               
LIABILITIES
              
Current liabilities
    
689,393
   
800,899
 
Long term liabilities
    
1,926,380
   
2,468,275
 
               
TOTAL LIABILITIES
    
2,615,773
   
3,269,174
 
               
STOCKHOLDERS' EQUITY
              
Paid-in capital
    
6,290,745
   
6,051,262
 
Loan receivable from Director / CEO
   
(1,000,000
)
  
(1,000,000
)
Accumulated other comprehensive income
    
1,675,092
   
2,537,963
 
Retained earnings
   
2,020,542
   
3,775,376
 
               
TOTAL STOCKHOLDERS' EQUITY
    
8,986,379
   
11,364,601
 
               
TOTAL LIABILITIES & STOCKHOLDERS' EQUITY
  
$
11,602,152
  
$
14,633,775