UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13D

Item 1.

Security and Issuer

This Statement on Schedule 13D relates to shares of common stock, par value $0.01 per share (the “Common Stock”) of Pressure BioSciences, Inc., a Massachusetts corporation (the “Issuer”).  The principal executive offices of the Issuer are located at 217 Perry Parkway, Gaithersburg, MD 20877.

Item 2.

Identity and Background

(a)-(c)     This Schedule 13D is filed by Richard T. Schumacher (the “Reporting Person”).  The Reporting Person is the President and the Chief Executive Officer of the Issuer.  The business address of the Reporting Person is 217 Perry Parkway, Gaithersburg, MD 20877.

(d)-(e)     During the last five years, the Reporting Person has not been (a) convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors), or (b) a party to a civil proceeding of a judicial or administrative body of competent jurisdiction resulting in such person being subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

(f) The Reporting Person is a citizen of the United States of America.

Item 3.

Source and Amount of Funds or Other Consideration

On February 11, 2005, the Issuer completed an issuer tender offer to purchase up to 5,500,000 shares of its Common Stock at a purchase price of $3.50 per share.  Based on the final count by the depositary for the tender offer, 5,210,001 shares of common stock, which includes 761,275 shares issued upon exercise of stock options, were properly tendered and not withdrawn.  The Issuer accepted for purchase all 5,210,001 shares at a purchase price of $3.50 per share in accordance with the terms of the tender offer.   The Reporting Person sold 130,000 shares of Common Stock in the tender offer. As a result of the completion of the tender offer, immediately following payment for the tendered shares, the number of issued and outstanding shares of Common Stock of the Issuer will be reduced from 6,872,915 to 2,424,189 shares of Common Stock and the Reporting Person’s beneficial ownership will increase from 10.97% to 25.0%.

The Reporting Person purchased the shares of the Common Stock reported by him in Item 5 below in connection with the founding of the Issuer and used an aggregate of approximately $2,500 of personal funds for such purchase.

Item 4.

Purpose of Transaction

This Schedule 13D is being filed in connection with the transaction described in Item 3 above, pursuant to which the Reporting Person’s beneficial ownership increased from 10.97% to 25.0% because of the reduction in the number of issued and outstanding shares of the Issuer as a result of the tender offer described in Item 3 above.  As described in Item 3 above, the Reporting Person sold 130,000 shares of Common Stock in the tender offer.  No shares of Common Stock reported in Item 5 below were acquired by the Reporting Person except as described in Item 3 above.

Item 5.

Interest in Securities of the Issuer

(a)           As of the close of business on February 11, 2005, pursuant to Rule 13d-3(d), the Reporting Person was the beneficial owner of 637,907 shares the Common Stock, representing 25.0% percent of the Issuer’s issued and outstanding shares.  One hundred thirty thousand of these shares are issuable pursuant to stock options issued to the Reporting Person.

(b)           The Reporting Person has the sole power to vote or direct the vote and sole power to dispose or direct the disposition of the 637,907 shares of Common Stock.

(c)           Except as described in Item 4 of this Schedule 13D with respect to the sale of 130,000 shares of Common Stock by the Reporting Person in the tender offer, no transactions in the shares of Common Stock were effected by the Reporting Person during the past sixty days.

(d)           Not applicable.

(e)           Not applicable.

Item 6.

Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer

The Reporting Person has pledged 637,907 shares of Common Stock to a financial institution as security for a loan to an entity controlled by him.  The loan is personally guaranteed by the Reporting Person.  The Issuer maintains a junior subordinated security interest in these pledged shares in connection with a $1 million payment made by it pursuant to a guarantee of such loan.

Except as disclosed in Item 4 above or in this Item 6, the Reporting Person does not presently have any contracts, arrangements, understandings or relationships with any other person with respect to any securities of the Issuer, including but not limited to the transfer or voting of any shares of Common Stock, finder’s fees, joint ventures, loan or option arrangements, puts or calls, guarantees of profits, division of profits or loss, or the giving or withholding of proxies.

Item 7.

Material to Be Filed as Exhibits

Not applicable.

February 15, 2005

Date

/s/     Richard T. Schumacher

Signature

Richard T. Schumacher

Name/Title